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Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and <t>intratesticular</t> <t>testosterone</t> level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.
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Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and <t>intratesticular</t> <t>testosterone</t> level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.
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Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and <t>intratesticular</t> <t>testosterone</t> level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.
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Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and <t>intratesticular</t> <t>testosterone</t> level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.
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Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and intratesticular testosterone level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.

Journal: Frontiers in Endocrinology

Article Title: First in class monoclonal antibody potentiating human follicle stimulating hormone activity improves spermatogenesis in azoospermic rodent models

doi: 10.3389/fendo.2025.1668945

Figure Lengend Snippet: Effect of IGX12 in hpg mice. Testicular sperm count (A) , haploid/tetraploid cell ratio in testes (B) , sperm count in epididymides (C) , haploid cell count in epididymides (D) and intratesticular testosterone level (E) after treatment with either rhFSH and then hMG, or rhFSH+IGX12 and then hMG+IGX12. n=8 mice per group. Results were expressed as median with 10–90 percentile (*p<0.05 and **p<0.01) ns stands for non-significant.

Article Snippet: After testicular sperm reserve assessment, the sample is used to quantify the intratesticular testosterone levels using a commercially available kit from Cayman (Interchim, Montluçon, France).

Techniques: Cell Counting